Potential of comorbidity indices and CHA2DS2-VASc to predict ischemic stroke and mortality in patients with atrial fibrillation: a validation study
نویسندگان
چکیده
Abstract Background Atrial fibrillation represents a large health burden and increases the risk of ischemic stroke mortality. A proportion atrial patients also has other comorbidities. It remains unknown whether comorbidity summarized as score can predict mortality after fibrillation. In an aging population burdened with comorbidities, it thus become increasingly important to understand impact on prognosis Purpose We examined ability Danish Comorbidity Index for Acute Myocardial Infarction (DANCAMI), Charlson (CCI), Elixhauser (ECI), CHA2DS2-VASc all-cause within one year or flutter. Methods identified all first-time flutter hospital diagnosis in Denmark from 2000 through 2015 (n=318,939). comorbidities each index using diagnoses 10 years before For index, we calculated Harrell's C-Statistic stroke, mortality, cause-specific due cardiovascular diseases cancer hazard ratios association DANCAMI not included CCI flutter, conditioning age, sex, Results The was 0.64 (95% confidence interval [CI]: 0.63–0.64) DANCAMI, 0.63 CI: CCI, ECI, CHA2DS2-VASc. 0.74 0.74–0.75) 0.73–0.74) 0.73 0.72–0.73) 0.69 0.69–0.69) Among five predicted increased (epilepsy, alcohol drug abuse, schizophrenia, affective disorder, chronic kidney disease) eight (coagulopathy, neurodegenerative epilepsy, disease, pancreatitis). Compared better at predicting (C-Statistic=0.79, 95% 0.79–0.80) (C-Statistic=0.78, 0.76–0.80) Conclusion no well. However, par ECI than Funding Acknowledgement Type funding sources: None.
منابع مشابه
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2022
ISSN: ['2634-3916']
DOI: https://doi.org/10.1093/eurheartj/ehac544.373